![]() ASIO driver connects with computer sound card directly. We have provided multiple solutions in here. Introduction Installs Intel® Wireless Bluetooth® version 22.220.1 Driver version varies depending on the wireless adapter installed. It bypasses all the software layers that other audio drivers have to go through. 2023 6 Methods on How to Fix Generic Audio Driver Detected in Windows 10/11 Are you facing generic audio driver detected issue on your computer Trying to find a generic audio driver fix Read this article to learn various ways of how to fix generic audio driver. It helps reduce latency between audio applications and the computer sound card. It is a professional-level audio driver for Windows. We have had a few reports on Windows 10 where the driver will automatically install and the board will show up under a new COM port as USB-Serial CH340, but. The ASIO driver has some advantages over other audio drivers. On Windows, you can use various audio drivers for the audio input and output like ASIO, Realtek, MME/Direct X, Direct Sound, or Direct Capture. Introduction Installs Realtek High Definition Audio Driver for the 3.5mm audio jack for Windows® 10 64-bit and Windows 11 for Intel® NUC 11 Enthusiast Kit & Mini PC - NUC11PHKi7 Available Downloads Download Audio-Win10Win11-.1.zip Windows 11, Windows 10, 64-bit Size: 38. ![]() ASIO lets you set lower buffer sizes and provides a low latency between an application and the computer’s sound card.
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![]() ![]() In the following video, you see how to use both methods. Place the camera at a specific point, facing a specific direction. Hope this makes at least some sense, if it doesn't feel free to let me know and I'll make a tutorial with some pictures.Ĭheck out this link for some grass, this one might work well for you if you flip it horizontally. Looking around your model Walking through a model Positioning the camera You can position the camera using one of two methods: Place the camera at eye-level above a specific point (5 6' above that point by default). I used this technique here and here with a somewhat acceptable result. If you want to take it even further (like me usually) you can also use the 'grass brush on mask' method you already learned and apply this technique to the edges of your shadow. For more realism it's essential to add some gaussian blur to the mask, the value depending on how soft the sun was set for your actual render. ![]() You might need to invert the mask by pressing CTRL+I. Now change the lightness and saturation here to a lower value. Now you can use the magic wand tool on the layer with the SU-output to select the shadows you want to show on the 'real' grass, and with the selection still active go over to the adjustmentlayer's mask and fill the selection with black. Ive finally found out what the terrain edit tool works like, so I thought it would be fun to make a mountain house. Now add a hue/saturation adjustment layer above your grass image and make it clip to just that layer (by alt-clicking on the line between the two in your layers window). 43K 3.1M views 7 years ago Today Im back with a new Sketchup speed build. Copy it by using Ctrl+A and Ctrl+C, then going over to your project document and pressing Ctrl+V. Then you export the SU image with the same dimensions and load this into photoshop. Now turn on your shadows and in Shadow Settings set the Dark slider all the way to the left. Then choose a Style with a white background (like Engineering Style)and set your faces to hidden line. One solution I sometimes use is go to Sketchup and get the exact same view as you rendered. I wanted to try to fix the grass in the foreground but using the layer mask method would cover all of the foreground shadows Denton Corker Marshalls sculptural View Hill House in Yarra Valley, Australia, overlooks 78 acres of vineyards. David Santos set upon recreating Lake Lugano House, a beautifully designed house by JM Architecture, which he modeled using SketchUp 2015 and rendered with. ![]() ![]() ![]() Overall, I would probably give this particular book a rating of about 4.3 but its place as part of the series has meant that I have erred on the side of generosity to scrape it in with the full 5 star rating. This always was going to be a military space opera and the central character, Kyle Roberts is likeable, flawed but knows he could be better and generally gets things right by finding solutions to seemingly dire situations. A minority of reviewers have said that the characterisations are weak but I didn't notice that and those people that the author wanted us to focus upon seemed to be expanded to a suitable level. This one was a bit darker than the previous two episodes but lightened by a love story percolating in the background. ![]() The saga continues with this third book in the series and I have to confess that I am pretty much gripped by now. This 3rd instalment is by far the best in the series so far and is worth reading the entire series for, as it is an exceptionally brilliant book based around some of the best starship combat to date. The dialogue between the characters has developed with each novel, getting stronger, more realistic still with a good degree of humour which has been one of the highlights of this series, but tempered with a very real understanding of the life and death situations they are facing. Stewart must have spent hours planning the fine detail of the battles and laying out the very ships to have been able to describe these battles with such intricate detail.Īs with the 2nd story, the characters continue to grow, gaining more depth, Kyle now having relationships with not just his estranged ex-partner and son, but now a real partner. The other thing with Stewart’s books is that he doesn’t just take out the side-kicks or the redshirts, main characters die as well, so you never know what is going to happen, increasing the tension of the story.Īdded to that is the detailed strategy and tactics, not just detailed in the telling of the story, but discussed by the characters on both sides, giving you a unique perspective of the battle field as these incredible conflicts unfold with such exquisite detail. ![]() It is not just the descriptions of the actual battles, the technical details and the incredible accounts of missile by missile strikes, it is the characters, their input and reactions, the sheer tension he generates as fighters and capital ships launch thousands of missiles in a desperate struggle to survive. This book has some of the best space battles not just of this series, but of a lot of series that I have read. Kyle is sent on a daring mission, whilst the newly created 7th Fleet is sent deep into Terran territory to take out their shipping. Kyle Roberts is finally put to the test in this book, as the Alliance decide to strike back, going on the offensive, they suddenly find that they have been pulled into an interesting situation, a chance to end Terran control of the Sector, but also the chance for the Terran’s to cause some major damage. This was an incredibly intense book, one that once you get into, you find that you have a hard time actually putting down with all the amazing battles, and the effect of certain outcomes. Users may opt out of personalized advertising by visiting. Such advertising cookies may enable such third-party vendors to serve ads to our readers. ![]() Some third-party vendors such as Google use cookies to serve ads based on a user's prior visits to this and other websites. BookGorilla is published independently by Stephen Windwalker and Windwalker Media and is not endorsed by, Inc. This content is provided "as is" and is subject to change or removal at any time. Certain content that appears on this website is provided by Amazon Services LLC. Amazon, Kindle and the Amazon and Kindle logos are trademarks of, Inc. As an Amazon Associates participant, we earn small amounts from qualifying purchases on the Amazon sites, which in turn allows us to provide our editorial content FREE to readers.Īpart from its participation in the Associates Program, BookGorilla is not affiliated with Amazon or Kindle in any other way. While all titles recommended by BookGorilla must meet our standards for price, quality, and appropriate content, some publishers or rightsholders compensate us for prominent placement on the site or in our email bulletins.īookGorilla is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to. Copyright © 2007 - 2023 Windwalker Media. ![]() ![]() ![]() The gameplay I got to see was pre-alpha but it looked good: fluid and responsive. It’s got a contemporary crime angle, and it’s a story they want to tell. This is a reboot, a chance to go back to the origins. So over to the studio now, and Volition themselves start by saying “you may be wondering what we’ve been doing since Saints Row IV?” and, well yeah. Angry beard guy aims the launcher, but it’s okay ‘cos now he’s dead. But a huge neon mustachioed sign lands on his car. The angry over-sized beardy man is angrier than ever. Somehow the car is now on the roof of a building. The music is banging, a motorbike flies over the top of a stolen car. ![]() Then there’s a digital mask that reminds me of Watch Dogs 2. The humour is there right away, the characters are larger than life. There are mobile phones so it’s not ancient. ![]() Of course there’s still a thumping bass permeating throughout the track, but finger picked classical guitar and, look, the soundtrack already seems killer, okay? Saints Row: the reveal trailer When a reveal starts with a spaghetti Western remix of the Saints Row theme you know something is about to go down. Also, the new Saints Row looks brilliant. Oh, by the way, I’ve seen the new Saints Row and it’s a reboot. But that’s because that game doesn’t exist. What it wasn’t, was as good as Saints Row IV. It wasn’t a new Saints Row game, but it also sort of was. How do you follow up something like Saints Row IV? Being pretty brutal about it, Volition’s 2017 release Agents of Mayhem suggested that the studio itself wasn’t entirely sure, either. ![]() ![]() ![]() We have people on set to advise us when we have big military scenes so they make sure that we are as accurate in our portrayal as possible! I started kickboxing to toughen up physically and kept reading anything I could get my hands on! We also had a few days of training with our military advisor at the time Ron Blecker, he was very open with us and helped me get into the mindset of someone in my position. When I got the role, it was really important to me to study as much about the military as I could. Vanessa James and I knew that I had found the role I wanted! The audition was pretty quick and a week or so later, I was cast. ![]() Riley (Haig Sutherland) and Andrea Palmer (Christina Schild) were the two parts that the producers were apparently considering me for and then I read one page of sides for 2nd Lt. JB: I auditioned for a few characters on SGU before I read anything about Vanessa James. I am watching Fringe on DVD right now and season 2 is fantastic. JB: Firefly and Fringe are 2 shows in the sci-fi genre that I love. GD: Are you a fan of any SF movies, books or other properties? I had a great time, Richard Kind was hilarious and the cast of SGA was great! I have also done an episode of Supernatural and Smallville. I ended up doing an episode of SGA called “Irresistible” with Richard Kind. JB: Being a Vancouver actor, I had auditioned many times for both SG1 and Atlantis. To be honest, my husband Peter has done a ton of commercials and he usually gets recognized a lot more than I do! Lol I usually have my hair down and I look a lot different in street clothes. People who do recognize me from the show usually stare and then it takes them a minute to place me. JB: A few times I have been stopped in Vancouver. GD: Do you get recognized or stopped by fans on the street? Any interesting stories there? The important thing to me is to believe in what I am doing in life. Everyone is entitled to his or her opinion, and not every show is for everyone. You have to develop a thick skin to be in this business and take everything, compliments and criticism, with a grain of salt. They are the reason we’re on the air!! As far as the scrutiny goes I give it very little attention. ![]() JB: I am honored to be a part of a show and a genre that have such loyal fans. What’s it like to work with the eye of fandom upon you? SF fans are known both for their loyalty and scrutiny. GD: You’ve become associated with a very popular science fiction series. I don’t know if damsel in distress is up my alley I am more drawn to quirky characters in comedies. JB: It’s funny, I often play strong women but I have a ton of fun playing softer characters. GD: You seem to play a very strong part in SGU, would you ever want to play the damsel in distress? That being said, I have loved being a part of this world and am definitely into working in this genre again! I always want to play the opposite of what I just played. It’s important for me to always be challenged with new material. JB: I love working as an actor but I don’t want to be limited to one genre. GD: Would you mind if you started getting type-cast for sci-fi movies and TV? I definitely want to go to conventions as I am really looking forward to meeting some of our fans! I have been invited to a few but unfortunately the timing just hasn’t worked out. GD: Have you been to any of the Sci Fi Conventions? Do you plan on making the rounds to conventions from now on? Having some sense of stability as an actor is a good thing! It has definitely opened me up to the sci-fi genre and helped me generate some buzz, so I am grateful for that. JB: Stability! Stargate has been a great experience for me, it’s nice to come to a job that you love all the time. GD: Has anything changed for you since you started Stargate: Universe? (We take a month off in the summer.) So there were no conflicts at all! It can definitely be hard to work on other shows while filming SGU as you never know how many days you’re going to be working in each episode. It started shooting the day after our hiatus started. Julia Benson: Grim destiny for James, I hope not! But you’ll have to watch and see! I was very lucky with the timing of Earth’s Final Hours. GeekDad: Has Earth’s Final Hour or any other projects take you away from Stargate Universe? Could there be a grim “destiny” in store for Lt. Vanessa James on the fan-favorite sci-fi series SGU: Stargate Universe. Julia’s character is Chloe Edwards, a no-nonsense professional who works with the Science Division of the Defense Administration and is assigned to investigate a baffling anomaly.Currently however, she plays her popular role as 2nd Lt. The movie also stars Robert Knepper ( Prison Break). In case you haven’t heard already, she has just been cast as the female lead in Earth’s Final Hours, to be directed by David Hogan for Syfy. GeekDad recently had a chance to ask a few questions to the lovely Julia Benson from Stargate: Universe. ![]() ![]() ![]() UtilitiesĪlong with utilities such as the cleaning of old and large files, a duplicate finder, and a file eraser (which will securely remove any selected files, a function that Apple has disabled in the latest versions of macOS for Macs with flash storage), MacClean also includes the convenient app uninstaller. So, if you don't have a third-party Mac malware app such as MalwareBytes then you might want to restrict how often you use it, or otherwise skip it completely. This is essentially the open-source ClamAV scanning engine, which is a super-slow resource hog when run on demand. But before the scan can be initiated you'll first be prompted to install a MacClean security database and engine. One interesting feature included in the cleaning module is the function to scan your whole Mac, Application and Download folders, or a selected folder for malware. ![]() The results of the scan are then displayed in an easy-to-understand manner, along with the option to review the files the cleaning software has flagged as junk. ![]() MacClean, however, needs much more attention since it will perform scans in only the specifically chosen areas, whether that’s system or internet junk files, malicious cookies or looking for security issues on demand. Competitors such as CleanMyMac offer convenient automation processes, meaning that you only need to push one button to get information on how much disk space you are about to free up. MacClean makes it easy to remove useless junk files, but it doesn't help save time at all. It also features a script called security issue, which will analyze your computer for potential virus threats based on a third-party virus database and search engine that you'll need to download first. It also looks for app documents and private app histories, and gives users the option to remove these cache files to protect their privacy. But what makes this app particularly interesting is its ability to scan web browsers (Safari, Google Chrome, Firefox or Opera) for malicious cookies. Just like its competitors, MacClean seeks to clean your Mac of system cache junk (user cache, system cache, developer junk files and app leftovers) and internet junk data such as browsing histories, download histories, cached files and cookies. The app incorporates two main modules, cleanup and utilities, each of which has a list of actions you can take to optimize your Mac. When you launch MacClean you're greeted by a simple, basic and easy-to-understand user interface with a list of functions on the left side of the window. However, to perform a cleaning operation you will need to buy a lifetime license for as low as $7.99. ![]() In its free form this Mac optimization software will scan your computer on demand and display how much data can be safely removed from the startup disk. MacClean is a freemium app, meaning it can be downloaded and used for free, although limitations do apply. Alongside apps targeting iPhone, iPad and iPod users, such as AnyTrans (for managing file transfers), PhoneRescue and PhoneClean, MacClean is designed solely to keep your Mac clean and safe from malware. IMobie, a China-based company established in 2011, built its business around Apple's: the team of developers is focused on iOS device content management, iOS data recovery and Mac utility software. ![]() ![]() The uncertainty of Tua’s health is a minor concern, however the Dolphins added an insurance policy in former New York Jets quarterback Mike White, who flashed last season. His ceiling and floor dropped significantly when Tua was not behind center last season. Waddle led the NFL with 11.1 yards per target and 18.1 yards per catch. Jaylen Waddle and Tyreek Hill formed an explosive duo of wideouts in Miami and helped many fantasy managers to their playoffs. Probably the most hyped player in fantasy football. Diggs provides elite-level fantasy numbers and is an outstanding choice as a WR2 in my weekly lineup.Īlternative Selection: Garrett Wilson. The Bills drafted TE Dalton Kincaid in the first round of the 2023 NFL Draft to provide another offensive weapon and open things up for quarterback Josh Allen. He continues to produce at an elite level without a considerable threat to help him in Buffalo’s passing offense. He has averaged 113 receptions and ten scores across the past three seasons. Diggs has produced three consecutive top-10 finishes since he arrived in Buffalo. It is hard to argue with picking the WR5 from last season. Just imagine what numbers Chase will produce in an entire 17 game season! This is a no-brainer selection.Īlternative Selection: N/A Pick 2.09: Stefon Diggs (WR – BUF) Chase plays in an explosive offense that includes a top-20 wideout ( Tee Higgins), a top-15 RB ( Joe Mixon), and his best friend and top-4 quarterback ( Joe Burrow) at the helm. ![]() The former LSU Tiger was able to accomplish those numbers in just 13 games as he missed time throughout the season due to a hip injury. Chase finished as the 12th-best overall WR last season and had a career-high 87 receptions for 1,046 yards and nine touchdowns. With Jefferson off the board, Chase was an easy pick and an excellent start to your three-wide receiver lineup. ![]() Chase and Justin Jefferson will be dueling it as the top fantasy wideouts for the next three to five seasons. Pick 1.04: Ja’Marr Chase (WR – CIN)įantasy managers should be ecstatic if Ja’Marr Chase falls to them at their fourth pick. This mock draft is for a league with weekly lineups consisting of one quarterback, two running backs, three wide receivers, one tight end, and two flex spots. Redraft PPR Mock Draft: 12-Team 1-QB (2023 Fantasy Football) Expert Consensus Fantasy Football Draft Rankings.Snake Draft Pick Strategy: Early | Middle | Late.I was assigned the fourth pick and used our Fantasy Football Mock Draft Simulator to draft a team and provide analysis through 17 selections. I conducted a 12-team mock draft using point per reception (PPR) scoring with one Quarterback to assist fantasy football managers in preparing for their upcoming drafts. Learn where the value drops off at each position. Find out when is the best time to take a quarterback or a tight end. You can obtain invaluable knowledge by conducting mock drafts, including different strategies and how to draft with tiered cheat sheets. One of the most effective methods in gaining the edge is conducting mock drafts. It is never too early to prepare for your fantasy football drafts. ![]() ![]() ![]() The price of the item may decrease or increase from delivery to delivery, depending on the price of the item at the time they process your order. NOTE - In advance of each delivery, Amazon will send you a reminder email showing the item price and any applicable discount for your upcoming delivery. ![]() That means if you’re just wanting to snag a deal for the low price but don’t want the subscription, you can cancel it right after you receive your order.Īlso, you can unlock extra savings on select subscriptions by clipping coupons, and you can save an extra 15% instead of the regular 5% off all items in your subscription whenever you add 5 or more eligible items to your monthly subscriptions. You can also cancel your subscriptions easily in your Amazon account without being penalized. With Subscribe & Save, you'll score free standard shipping on auto-deliveries (non-Prime customers may incur shipping costs for the first delivery). Prime members also score Free One-Day Shipping on millions of products! Check out even more of the best Amazon Prime benefits here! ![]() ![]() Checkout Don't Waste Your Money for product reviews and other great ideas to save and make money.Get free shipping on a $25 order OR snag free 2-day shipping on ANY size order with Amazon Prime (you can sign up for a FREE 30-day trial here). This story originally appeared on Don't Waste Your Money. New users can input the coupon code “KEY30” to get $30 in Amazon credit. In-Garage Delivery requires a Chamberlian MyQ smart garage device ( about $30 on Amazon) and gives the Amazon driver a one-time code that opens the garage once they’ve scanned your package. If you’re tired of worrying about porch pirates or your packages being exposed to the elements, you can now have Amazon drivers leave your package inside your garage by signing up for Amazon Key.Ĭonsumer Reports has recommended signing up for this feature if you’re worried about thieves ripping off your packages. If you’re looking to save even more money while shopping on Amazon, the retail giant is currently running a promo for users who sign up for In-Garage Delivery. Once you’ve set up a delivery schedule, you can always change the details by visiting “Manage Your Subscriptions.” Duracell Coppertop AA and AAA alkaline batteries contain Duracells patented POWER BOOST Ingredients which deliver lasting performance in. There are thousands of products eligible for the Subscribe and Save option on Amazon, including cleaning products, toilet paper, diapers, pet food, vitamins, trash bags and laundry detergent. PARIS, FRANCE – JAN 13, 2018: Woman next to stack of Amazon Prime packages delivered to a home door impatient unboxing unpacking That can be a hefty discount on stuff like laundry detergent and cleaning supplies that you have to regularly buy anyway. And, if you subscribe for five items for auto-delivery in a shipment, you will save a whopping 15% on each item. When you sign up for Subscribe and Save, you will save 5% on those purchases. The most popular subscription option is an automatic order every two months but you can schedule it in intervals ranging from every two weeks to every six months.Īmazon’s Subscribe and Save option is a good way to ensure that you never run out of household needs like batteries while also ensuring that you are saving money on them. With that box ticked, the price will drop to $4.68, and you will be subscribed to have batteries sent to your door in regular intervals. However, if you frequently go through a lot of batteries, you can save even more by clicking the “Subscribe and Save” option. With the coupon being offered right now, you can get 28 Duracell AA batteries for just $9.79 ($10.33 after-tax)! To get the deal, just make sure you have the “One-Time Purchase” option checked, rather than “Subscribe and Save.” (Regularly, a pack that size would cost you upwards of $20).īut you can actually get these batteries for even less on Amazon if you make sure to apply the coupon before adding them to your cart. Right now, for a limited time, you can get a 28-pack of Duracell AA batteries for less than $12 on Amazon. However, Don't Waste Your Money may receive a small commission from the purchase of any products or services through an affiliate link to the retailer's website.īatteries are notoriously expensive, but if you shop smart, you can save big on these household essentials. The products and services mentioned below were selected independent of sales and advertising. ![]() ![]() You won’t have to install it separately if you have Tasks in the desktop client, you’ll see it on your web and mobile clients too. Tasks will come to the mobile Teams app later (after it’s finished rolling out to Microsoft 365 and Office 365 tenants), so it doesn’t have to go through the name changes and will just be called Tasks as soon as it shows up. Later in the year the name changes again to Tasks. ![]() “Rather than building a brand-new experience inside Teams, it’s really about evolving Planner and To Do and bringing those existing experiences inside Teams,” Angela Byers, director of product marketing for Microsoft 365, told TechRepublic.Īfter a few weeks, the app will be called Tasks by Planner and To Do, which is one of Microsoft’s typical ‘does what it says on the tin’ names that should make it less of a surprise that your tasks from To Do are showing up. So if you already have it installed, you should get the new features by September, but you will still see the Planner name in the Teams desktop client. The new Tasks app is really an update to the Planner app, with new features and (eventually) a new name. The Planner app is already available inside the Teams client, but previously it showed a board view of all your Planner tasks, plus new tasks assigned to you in the main Activity feed and the full Kanban board and calendar views if you added a Planner plan to a specific channel as a tab. ![]() This approach should also reassure everyone that Planner and To Do aren’t going away in favour of a new Tasks app, because while you can see tasks in the same place, they will continue to have different features depending on the app in which they were originally created. SEE: Office 365: A guide for tech and business leaders (free PDF) (TechRepublic)īut the name for the new way to look at tasks in one place is going to change several times, in an attempt to help people who are familiar with the separate Planner and To Do tools get used to the new option. It includes a new way for firstline workers and personal users to get tasks and some other Planner features, and marks significant progress in unifying tasks across different Microsoft tools and services. The integration of Planner and To-Do into Teams as the Tasks app, announced last year at Ignite, is now finally starting to roll out, creating a single place to see tasks from multiple sources. Even when Microsoft introduced new task management tools - Planner for team tasks and To Do (based on Wunderlist) for individual tasks - that used the Exchange task format from Outlook rather than creating yet another task format, connecting the different task lists meant extra work: installing the To-Do app or Planner app in Teams, or creating Power Automate flows. To get in touch about our Microsoft 365 Business solution, please fill out the form below.For many years, Microsoft has had isolated tasks in different systems: Outlook, OneNote, Project, SharePoint and Azure DevOps all had separate task lists with no single place to see everything you needed to do. So these are our chosen best 3 features of Microsoft Planner! We hope these help you in your daily use of Planner, if you don’t already have this – check out our page on Microsoft 365 for license plans that include it. This is great for if someone isn’t active on a plan for a day or so, they can keep up with the progress via OneNote. Office 365 is well known for its collaboration features and one of these great collaboration pairings is between OneNote and Planner.īy clicking ‘Notebook’ on in one of your plans, OneNote will create a brand new notebook designated to the plan.Īll individuals within the plan can write in the notebook and keep updating it with information! You can also rename the label with ‘High Priority’, and this text will appear alongside the attached label Planner Notebook ![]() If one task is of high priority we will give a red label, a moderate priority task receives an orange label, and low priority tasks receive a green one. You can define what you want the labels to mean, as an example, we use coloured labels to represent task priority. Planner allows you to label your individual tasks using a colour coding system. ![]() Planner has a unique feature that you can use to help stay organized and keep on top of team tasks.Īll the tasks that you have within a plan can be viewed as a pie chart, which is further divided into task progress.Īll your completed tasks will appear as green – in progress tasks will appear as blue – late tasks will appear as red and tasks not started will appear as yellow.Ĭhart view will also display which tasks are assigned to which member. It offers some fantastic ways to organize your tasks and teams. Microsoft Planner is a planning application and great component of Microsoft 365, available to premium, business, and educational subscribers. ![]() ![]() Dizziness incapacitates me, and I cannot be an effective researcher, educator, husband, or father. With no disrespect or insensitivity intended toward the hearing impaired community-of which I am a passionate member-I would take hearing loss over vertigo in a heartbeat. I honestly cannot do anything-I can only hope to fall asleep quickly. I must lie down until the dizziness subsides, which is usually 12 to 16 hours. When I have an acute attack of dizziness, my visual field scrolls from right to left very quickly so that I must close my eyes to avoid profound motion sickness and vomiting. The clinical data do not fit with a diagnosis of Ménière’s disease, and the link between my vertigo and hearing loss is unclear. I have benefited immeasurably from the scientific community that makes up the Association for Research in Otolaryngology, whose meetings have world-class assistive listening technologies and interpreter services plus overwhelming support of members who have hearing loss.Īs I entered my 40s, I experienced vertigo for the first time. I also reasoned that the auditory research conferences and meetings I’d be attending would likely have assistive listening technology to allow me to participate more fully. When picking my area of scientific focus, I settled on a career in auditory neuroscience to better understand hearing loss. While I do not consider my hearing loss to be a profound limitation personally or professionally, it has certainly sculpted my career path. During postdoctoral training in auditory neuroscience at Purdue University, I was given complimentary assistive listening technology upon my arrival to the lab. I asked my professors and classmates to face me when they spoke so I could use visual cues to enhance oral comprehension. At Boston College (where I received my undergraduate, Master’s, and Ph.D., all in the biological sciences) I sat in the front seat of my classes, as close to the speaker as possible. I continue to use a hearing aid in my right ear, and thankfully for the past eight years, my hearing has remained stable, if stably poor. In graduate school I began using hearing aids and later received a cochlear implant in my left ear. Over time my hearing loss became bilateral and progressive, and its cause remains unknown. In grade school, I simply tilted my right ear toward sound sources. Managing the loss of a primary sense is all about adaptation. The audiologist explained to me that as a result, I may not be able to hear birds singing as easily, and that I may need to concentrate more to understand words starting with “sh,” “k,” or “t.” Sensing my alarm, she tried to reassure me by saying it was unlikely that the hearing loss would affect both ears, and if it did, it would likely not be to the same extent. I was about 9 when hearing loss in my left ear was first detected. For more, see her Biochemistry paper:, “The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. Susan Robey-Bond, Ph.D., was a 2012 Emerging Research Grants recipient. How these proteins are implicated in the hearing processes will eventually help develop cures or better treatments for Usher syndrome. ![]() More specifically, cells from patients containing the Y454S mutation displayed lower levels of protein synthesis, which could explain the onset of deafness these patients experience. In later analysis, though, the team found that at an elevated temperature the Y454S substitution was less stable than the wild-type. ![]() The amino acid activation, aminoacylation, and tRNA binding functions were all consistent between the mutation and wild-type genes. The team studying the biochemical properties of the gene compared the Y454S mutation in the HARS enzyme with its wild-type (non-mutated) form and found similar functional biochemical characteristics, as stated in the researchers’ recent paper in Biochemistry. It is caused by a USH3B mutation, which substitutes a serine amino acid for a tyrosine amino acid in HARS. Usher syndrome type 3B is autosomal recessive, meaning children of parents carrying the gene but who do not display symptoms have a likelihood of developing the disease. ![]() |
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